10, 11 Other challenges 12− 15 include refractive indexes similar to that of the surrounding medium, Of cells spanning a broad size range from the sub-micrometer level Protein agglomerates 9 and different types The analysis of these particles, forĮxample, in terms of their size distribution, presents a range ofĬhallenges, including the presence of multiple populations such as Surveys, 6− 8 there is an increasing need for analytical toolsĬapable of rapidly measuring critical quality attributes of complexīiological particle samples. The development of advanced therapeutics 3− 5 and encompassing ecosystem This study provides confidence in the use of LD for the measurement The relative concentration of the particle populations in the mixed The method was also found to be useful for estimating Method repeatability was found to be robust, withĭeviations below 1%. Particles larger than 1 μm and generally within 25 % for the Measured by LD for the mixed suspension was accurate within 2 % for ![]() We found that the modal diameters of the particle size distribution The selection of the algorithms and validate the measured size distributions. Independent methods were applied to guide We discuss the application of differentĪvailable algorithms to the analysis of the data and their impact Mixed populations of polystyrene particles with diameters rangingįrom 60 nm to 40 μm. Of LD for the measurement of the modal diameter of both single and Of multiple particle populations whose modal size may span across Among theĬhallenges that these types of samples present, there is the presence ![]() ![]() Measurement of complex biological systems have increased. (LD) is a well-established tool for the measurement
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